CME ArticleUncommon Histopathological Variants of Malignant Melanoma. Part 2Saggini, Andrea MD*; Cota, Carlo MD†; Lora, Viviana MD†; Kutzner, Heinz MD‡; Rütten, Arno MD‡; Sangüeza, Omar MD§; Requena, Luis MD¶; Cerroni, Lorenzo MD║Author Information *Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; †San Gallicano Dermatological Institute, Rome, Italy; ‡Dermatopathology Friedrichshafen, Friedrichshafen, Germany; §Department of Pathology, Wake Forest School of Medicine, Winston Salem, NC; ¶Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and ║Research Unit Dermatopathology, Department of Dermatology, Medical University of Graz, Graz, Austria. Correspondence: Lorenzo Cerroni, MD, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria (e-mail: [email protected]). All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations relevant to this educational activity. The American Journal of Dermatopathology: May 2019 - Volume 41 - Issue 5 - p 321-342 doi: 10.1097/DAD.0000000000001226 Buy Metrics Abstract Despite new horizons opened by recent advances in molecular pathology, histological evaluation still remains the diagnostic gold standard regarding cutaneous melanocytic neoplasms. Several histological variants of melanoma have been described, and their knowledge is crucial for accurate diagnosis and classification of cases with unusual clinico-pathological features. Uncommon histological variants of melanoma have been described based on a broad constellation of features, including architectural pattern, stromal alterations, cytological attributes, and other morphological properties. This review is aimed at providing an extensive discussion of unusual but distinctive histopathological variants of melanoma. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.