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Reflectance Confocal Microscopy Features of Plaque Psoriasis Overlap With Horizontal Histopathological Sections

A Case Series

Verzì, Anna Elisa, MD*; Lacarrubba, Francesco, MD*; Caltabiano, Rosario, MD; Broggi, Giuseppe, MD; Musumeci, Maria Letizia, MD*; Micali, Giuseppe, MD*

The American Journal of Dermatopathology: May 2019 - Volume 41 - Issue 5 - p 355–357
doi: 10.1097/DAD.0000000000001297
Brief Report

Abstract: Reflectance confocal microscopy (RCM) displays horizontal, en face tissue sections of the epidermis and upper dermis, and interpretation of its features is classically based on the comparison with vertical conventional histopathological sections that, as known, do not reflect the same plane of observation. In 10 patients affected by psoriasis, we correlated RCM images with horizontal histopathological sections from skin biopsies, observing in all cases marked overlaps between the 2 techniques. Although vertical section examination remains the gold standard for the diagnosis of psoriasis, this novel comparative approach may contribute to a more precise definition of RCM findings and could represent the drive for further research as well as an innovative tool for educational purposes.

*Dermatology Clinic, University of Catania, Catania, Italy; and

Department “G.F. Ingrassia,” Section of Anatomic Pathology, University of Catania, Catania, Italy.

Correspondence: Giuseppe Micali, MD, Dermatology Clinic, University of Catania, Via S. Sofia 78, Catania 95123, Italy (e-mail:

The authors declare no conflicts of interest.

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