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Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks

A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

Konstantinova, Anastasia M., MD, PhD*,†,‡; Kyrpychova, Liubov, MD§; Nemcova, Jana, MSc, PhD§,¶; Sedivcova, Monica, MSc; Bisceglia, Michele, MD; Kutzner, Heinz, MD**; Zamecnik, Michal, MD††; Sehnalkova, Eva, MD‡‡; Pavlovsky, Michal, MD§§; Zateckova, Kamila, MD¶¶; Shvernik, Sergej, MD║║; Spurkova, Zuzana, MD║║; Michal, Michal, MD§,¶; Kerl, Katrin, MD***; Kazakov, Dmitry V., MD, PhD§,¶,***

The American Journal of Dermatopathology: April 2019 - Volume 41 - Issue 4 - p 281–285
doi: 10.1097/DAD.0000000000001285
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Abstract: Syringocystadenoma papilliferum (SCAP) is a benign tumor most commonly located on the head and neck area often associated with nevus sebaceus. In its usual location, the human papillomavirus (HPV) DNA and mutations in the RAS/mitogen-activated protein kinase signaling pathway have been detected in SCAP. We studied 16 cases of SCAP in the anogenital areas and buttock where this neoplasm is rare and attempted to find out whether SCAP in these sites have different histopathological and molecular biological features. It seems that there is no significant difference between the morphology of anogenital SCAP and SCAP in other locations. Several tumors in our cohort demonstrated features resembling those seen in warts, but HPV DNA was not found in these lesions. On the contrary, we identified DNA of HPV high-risk types in some tumors without HPV-related morphology. Our study confirms the role of HRAS and BRAF V600 mutations in the pathogenesis of SCAP, including SCAP in the anogenital areas and buttock.

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint-Petersburg, Russia;

Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint Petersburg, Russia;

Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia;

§Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic;

Bioptical Laboratory, Pilsen, Czech Republic;

Anatomic Pathology, School of Biomedical Sciences, Etromapmax Pole, Lesina (FG), Italy;

**Dermatopathologische Gemeinschaftspraxis, Friedrichshafen, Germany;

††Agel Laboratory of Pathology, Novy Jicin, Czech Republic;

‡‡Department of Pathology, Silesian Hospital, Opava, Czech Republic;

§§Department of Pathology, Regional Hospital Most, Czech Republic;

¶¶Department of Pathology, Regional Hospital Decin, Decin, Czech Republic;

║║Department of Pathology, Bulovlka Hospital, Prague, Czech Republic; and

***Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Correspondence: Dmitry V. Kazakov, MD, PhD, Sikl's Department of Pathology, Charles University Medical Faculty Hospital, Alej Svobody 80, 304 60 Pilsen, Czech Republic (e-mail: kazakov@medima.cz).

Supported in part by the Charles University Research Fund (Project number SVV-2018 - 260 391).

The authors declare no conflicts of interest.

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