Pityriasis Rubra Pilaris With Extensive Follicular Acantholysis Resembling Pemphigus Vulgaris A Case ReportLilo, Mohammed T., MD*; Yan, Shaofeng, MD, PhD*; Chapman, Michael Shane, MD†; Linos, Konstantinos, MD*The American Journal of Dermatopathology: January 2019 - Volume 41 - Issue 1 - p 37–39 doi: 10.1097/DAD.0000000000001222 Brief Report Abstract Author InformationAuthors Article MetricsMetrics Abstract: Pityriasis rubra pilaris (PRP) is a rare, chronic, heterogeneous, papulosquamous inflammatory dermatosis of unknown etiology. Although erythematous scaly patches characterize the classic presentation of PRP, a broad range of clinical presentations has been reported. Histologically, PRP is characterized by psoriasiform acanthosis with alternating orthokeratosis and parakeratosis and rarely small acantholytic foci. In this article, we report a patient who presented with diffuse erythroderma and extensive acantholysis mimicking pemphigus vulgaris histologically. *Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, Lebanon, NH; and †Section of Dermatology, Department of Surgery, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine, Lebanon, NH. Correspondence: Konstantinos Linos, MD, Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, 1 Medical Center Drive, Lebanon, NH 03756 (e-mail: Konstantinos.firstname.lastname@example.org). The authors declare no conflicts of interest. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.