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The “Line Sign” Is a Rapid and Efficient Diagnostic “Test” for Morphea

Clinicopathological Study of 73 Cases

Yang, Sarah, BS*; Draznin, Michelle, MD; Fung, Maxwell A., MD

The American Journal of Dermatopathology: December 2018 - Volume 40 - Issue 12 - p 873–878
doi: 10.1097/DAD.0000000000001177
CME Article
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Abstract: Histologic clues that facilitate rapid diagnosis of morphea at scanning magnification have been described but not well studied. We examined 73 cases of morphea and 42 control cases to determine the sensitivity and specificity of a novel histopathological feature—“the line sign (LS)”—a prominent, straight interface between subcutis and adjacent collagen. The sensitivity of LS was shown to be the most sensitive feature among 4 other existing histopathological features. Its specificity, however, was not the highest among the other features and needs to be evaluated further in future studies to confirm the usefulness of LS as a diagnostic tool for morphea.

*Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA;

Department of Dermatology, Arapahoe Medical Offices, Kaiser Permanente, Colorado Permanente Medical Group, Centennial, CO; and

Professor of Clinical Dermatology and Pathology Director, UC Davis Dermatopathology Service Executive Vice Chair of Academic Affairs, Department of Dermatology, University of California Davis School of Medicine, Sacramento, CA

Correspondence: Maxwell A. Fung, MD, UC Davis Dermatopathology Service, Department of Dermatology, University of California Davis School of Medicine, 3301 C Street, Suite 1400, Sacramento, CA 95816 (e-mail: maxfung@ucdavis.edu).

UC Davis 2017 Medical Student Research Fund.

All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations relevant to this educational activity.

Presented in part at the 42nd Annual Meeting of the American Society of Dermatopathology; October 20–23, 2005; Seattle, WA.

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