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Oncocytic Metaplasia in Melanocytic Tumors

Ahn, Christine, MD*; DeSantis, Emily, MD; McCalmont, Timothy, MD

The American Journal of Dermatopathology: December 2018 - Volume 40 - Issue 12 - p 899–902
doi: 10.1097/DAD.0000000000001159
Brief Report

Oncocytic metaplasia represents a histopathologic feature that can be observed in normal tissue such as salivary and lacrimal glands but may also constitute a degenerative metaplastic process as a result of repeated oxidative damage during cellular aging. Although cutaneous oncocytic metaplasia has been considered rare, the finding was seen in over one-third of melanocytic nevi prospectively evaluated, in one study. This case series reports on a small series of oncocytic melanocytic tumors, with the aim of describing this phenomenon in varied contexts and also describing the use of a mitochondrial antigen immunostain, which has not been previously reported.

*Department of Dermatology, Wake Forest School of Medicine, Winston Salem, NC;

Clinical Pathology Associates, Austin, TX; and Departments of Dermatology and Pathology, University of California, San Francisco, San Francisco, CA.

Correspondence: Timothy McCalmont, MD, UCSF Dermatopathology Service, University of California, San Francisco, 1701 Divisadero Street, Suite 280, San Francisco, CA 94115 (e-mail: tim.mccalmont@ucsf.edu).

The authors declare no conflicts of interest.

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.