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Campbell de Morgan Spots (Cherry Angiomas) Show Endothelial Proliferation

Fernandez-Flores, Angel, MD, PhD*,†,‡; Colmenero, Isabel, MD, PhD§,¶

The American Journal of Dermatopathology: December 2018 - Volume 40 - Issue 12 - p 894–898
doi: 10.1097/DAD.0000000000001216
Original Study

Abstract: Campbell de Morgan spots (also known as adult hemangiomas, cherry angiomas, or senile angiomas) show clinical and histopathological features that make them distinct. Despite this, they are not included as benign vascular tumors in the current classification by the International Society for Vascular Anomalies (ISSVA). In the current study, we investigated the proliferation rate (Ki67) of the endothelia of 23 cases of Campbell de Morgan spots, as well as the immunoexpression of Wilms tumor protein 1 (WT1) by these vascular anomalies. The youngest patient was 24 years old (range: 24–80; mean: 52.61). Ten patients were women (43.48%). All cases showed intense cytoplasmic expression of WT1 by the endothelia in 80%–100% of the endothelial cells. Ki67 demonstrated proliferation by the endothelia of all vascular lesions. A mean of 1077.6 nuclei were evaluated per case. Eight cases showed a very low proliferation (less than 0.5% of the nuclei). In the other 15 cases, the proliferation ranged from 0.59% to 3.59% (mean: 1.89%).

*Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain;

Department of Cellular Pathology, Hospital de la Reina, Ponferrada, Spain;

CellCOM-SB Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain;

§Department of Anatomic Pathology, Universitary Hospital of La Princesa, Madrid, Spain; and

Department of Histopathology, Birmingham Children's Hospital, Birmingham, United Kingdom.

Correspondence: Angel Fernandez-Flores, MD, PhD, Department of Cellular Pathology, Servicio de Anatomía Patologica, Hospital El Bierzo, Medicos sin Fronteras 7, 24411, Ponferrada, Spain (e-mail:

The authors declare no conflicts of interest.

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