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Verrucous Plaque With Unusually Large Candida Blastoconidia: A Unique Clinicopathological Presentation of Systemic Mucocutaneous Candidiasis

Rozas-Muñoz, Eduardo, MD*; Mozos, Ana, MD, PhD; Mir-Bonafé, Juan F., MD*; Cubiró, Xavier, MD*; Sánchez-Reus, Ferran, MD; Monteagudo, Carlos, MD, PhD§; Puig, Lluís, MD, PhD*

The American Journal of Dermatopathology: November 2018 - Volume 40 - Issue 11 - p 846–848
doi: 10.1097/DAD.0000000000001153
Extraordinary Case Report

Abstract: Mucocutaneous candidiasis is a common infection affecting both immunocompetent and immunosuppressed individuals. Diversity in the clinical and histopathological presentation of mucocutaneous candidiasis is well known. However, the occurrence of cutaneous verrucous lesions and giant yeast-like structures has been rarely reported. In this article, we describe a case of disseminated mucocutaneous candidiasis in an immunosuppressed patient who presented as a verrucous plaque on the scrotum with giant Candida blastoconidia. This peculiar presentation expands the clinicopathological spectrum of mucocutaneous candidiasis and highlights the wide range of clinical manifestations and great morphologic variability of this common fungal infection.

Departments of *Dermatology;

Pathology, and

Microbiology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; and

§Department of Pathology, Hospital Clínico Universitario/INCLIVA, University of Valencia, Valencia, Spain.

Correspondence: Eduardo Rozas-Muñoz, MD, Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Sant Antoni Maria Claret 167, 08025 Barcelona, Spain (e-mail: docrozas@yahoo.com).

E. Rozas-Muñoz, A. Mozos, J. F. Mir-Bonafé, X. Cubiró, F. Sánchez-Reus, C. Monteagudo, and L. Puig had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: E. Rozas-Muñoz, A. Mozos, J. F. Mir-Bonafé, X. Cubiró, and L. Puig. Acquisition of data: E. Rozas-Muñoz, A. Mozos, J. F. Mir-Bonafé, X. Cubiró, Sanchez-Reus, and C. Monteagudo. Analysis and interpretation of data: E. Rozas-Muñoz, A. Mozos, J. F. Mir-Bonafé, F. Sánchez-Reus, C. Monteagudo, and L. Puig. Drafting of the manuscript: E. Rozas-Muñoz, A. Mozos, and L. Puig. Critical revision of the manuscript for important intellectual content: E. Rozas-Muñoz, A. Mozos, F. Sánchez-Reus, C. Monteagudo, and L. Puig. Statistical analysis: Non applicable. Obtained funding: None. Administrative, technical, or material support: None. Study supervision: Non applicable.

The authors declare no conflicts of interest.

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