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Poxvirus-Induced Vascular Angiogenesis Mimicking Pyogenic Granuloma

Aşiran Serdar, Zehra, MD*; Yaşar, Şirin, MD; Demirkesen, Cuyan, MD; Aktaş Karabay, Ezgi, MD*

The American Journal of Dermatopathology: September 2018 - Volume 40 - Issue 9 - p e126–e129
doi: 10.1097/DAD.0000000000001138
Extraordinary Case Report

Abstract: The orf virus, a member of poxvirus family, is a zoonotic parapoxvirus endemic in many countries, mostly seen among sheep, goats, oxen, and may be transmitted to humans. Orf virus infections may induce ulceration, papulonodular, pustular, or ecthyma lesions in the skin. Rarely, orf virus provokes extensive vasculoendothelial proliferation by encoding an apparent homolog of the mammalian vascular endothelial growth factor family of molecules. The vascular endothelial growth factor–like viral gene product is expressed early during infection and could be responsible for the induction of endothelial proliferation. Here, a 6-year-old male patient with poxvirus-induced widespread vascular angiogenesis is presented, which developed ten days after a thermal burn.

*Department of Dermatology, Bahçeşehir University Medical Faculty, Istanbul, Turkey;

Department of Dermatology, Sağlik Bilimleri University Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey; and

Department of Pathology, Acibadem University Medical Faculty, Istanbul, Turkey.

Correspondence: Ezgi Aktaş Karabay, Department of Dermatology and Venereology, Bahçeşehir University Medical Faculty, İstanbul, Turkey (e-mail:

The authors declare no conflicts of interest.

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