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Fibrous Papule

A Histopathologic Review

Damman, Jeffrey MD, PhD*; Biswas, Asok MD, FRCPath, DipRCPath

The American Journal of Dermatopathology: August 2018 - Volume 40 - Issue 8 - p 551–560
doi: 10.1097/DAD.0000000000001083
CME Article

Abstract: Fibrous papule (FP) is a common benign lesion located primarily in the nose. Although its histogenesis has been marred with controversies in the past, the dermal dendrocyte is now largely accepted to be the putative cell of origin. Histopathologic diagnosis of an FP is straightforward in most cases, which shows characteristics of an angiofibroma. Several histologic variants have been described, recognition of which is important to avoid a misdiagnosis and inappropriate treatment. This review presents a historical perspective into the histogenesis, discusses the histopathologic features and potential diagnostic pitfalls of classic FP, and lists the various histologic variants and their differential diagnoses.

*Department of Pathology, Erasmus Medical Center, Rotterdam, the Netherlands; and

Department of Pathology, Western General Hospital and the University of Edinburgh, Edinburgh, United Kingdom.

Correspondence: Asok Biswas, MD, FRCPath, DipRCPath, Consultant Dermatopathologist and Honorary Senior Lecturer, Department of Pathology, Alexander Donald Building, Western General Hospital and the University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom (e-mail:

All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

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