CME ArticleVascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform HemangioendotheliomaJohnson, Emma F. MD*; Davis, Dawn M. MD†,‡,§; Tollefson, Megha M. MD†,‡; Fritchie, Karen MD¶; Gibson, Lawrence E. MD‖,**Author Information *PGY-4 Dermatology Resident, Department of Dermatology, Mayo Clinic, Rochester, MN; †Associate Professor, Department of Dermatology, Mayo Clinic, Rochester, MN; ‡Associate Professor, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN; §Fellowship Director, Pediatric Dermatology Fellowship, Department of Dermatology, Mayo Clinic, Rochester, MN; ¶Associate Professor, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; ‖Professor, Department of Dermatology, Mayo Clinic, Rochester, MN; and **Professor, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. Correspondence: Lawrence E. Gibson, MD, 200 First Street SW, Rochester, MN 55905 (e-mail: [email protected]). All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity The American Journal of Dermatopathology: April 2018 - Volume 40 - Issue 4 - p 231-239 doi: 10.1097/DAD.0000000000000983 Buy Metrics Abstract Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. We present the cases of 5 vascular tumors that have clinical and histologic overlap: infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma. Typical clinical and histopathologic features of each lesion are summarized. We review the utility and characteristic immunohistochemistry including CD31, CD34, GLUT-1, D2-40, LYVE-1, Prox-1, and WT-1. Collaboration between the clinician and the dermatopathologist correlating the clinical history and histopathologic features can lead to the correct diagnosis, whereas the utility of immunohistochemistry remains in question. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.