Original StudyMyxoid Spitz Nevi Report of 6 CasesFernandez-Flores, Angel MD, PhD*,†,‡; Riveiro-Falkenbach, Erica MD§,¶; Cassarino, David S. MD, PhD‖Author Information *Department of Cellular Pathology, Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain; †Biomedical Investigation Institute of A Coruña, CellCOM-SB Group, A Coruña, Spain; ‡Department of Cellular Pathology, Hospital de la Reina, Cellular Pathology, Ponferrada, Spain; §Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain; ¶Universidad Complutense, Medical School, Instituto i+12, Madrid, Spain; and ‖Department of Dermatology, Los Angeles Medical Center (LAMC), Southern California Kaiser Permanente, Los Angeles, CA. Reprints: Angel Fernandez-Flores, MD, PhD, Servicio de Anatomía Patologica, Hospital El Bierzo, Medicos sin Fronteras 7, 24411 Ponferrada, Spain (e-mail: firstname.lastname@example.org). The authors declare no conflict of interests. IRB status: IRB was not required. The American Journal of Dermatopathology: January 2018 - Volume 40 - Issue 1 - p 30-35 doi: 10.1097/DAD.0000000000000890 Buy Metrics Abstract Abstract: Mucin deposition in Spitz nevus seems to be a very rare phenomenon, as there have only been 3 cases previously published. We report 6 additional cases, half of them in women, and half in men. The ages of the patients varied from 5 to 47 years (mean = 30.17). Sizes of the nevi varied from 3 to 6 mm. Four lesions were located on the extremities, whereas one was located on the trunk (there was no clinical information about the other). A vascular lesion was suspected in 2 cases. Excision with clear margins was achieved in all cases but one. So far, there have been no recurrences after follow-ups varying from 1 to 5 years. The biopsy showed a symmetrical melanocytic Spitz nevus in all cases. Three cases were compound, and 3 cases were junctional nevi. The epidermis was either acanthotic or hyperplastic in all cases, with no epidermal consumption. Kamino bodies were found in 4 cases. The deposit of mucin was moderate in 5 cases and mild in one case. Mucin was found in the stroma between the dermal melanocytes in cases of compound nevi and in the melanocytic nests of the junctional component. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.