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An Immunohistochemical Study of Anogenital Mammary-Like Glands

Konstantinova, Anastasia M. MD, PhD*,†,‡; Stewart, Colin J. R. FRCPA§; Kyrpychova, Liubov MD; Belousova, Irena E. MD, PhD*,‡,‖; Michal, Michal MD¶,**; Kazakov, Dmitry V. MD, PhD¶,**

The American Journal of Dermatopathology: August 2017 - Volume 39 - Issue 8 - p 599–605
doi: 10.1097/DAD.0000000000000724
Original Study

Abstract: Although the normal histology of anogenital mammary-like glands (AGMLG) has been studied, no systemic investigation has been performed on the immunoprofile of these structures. We studied intact AGMLG with a broad panel of antibodies. The immunoprofile of AGMLG is similar to that of a normal breast tissue, and there are similarities to eccrine glands and coils about cytokeratin expression. Our immunohistochemical data may contribute to understanding of the pathogenesis of lesions arising from AGMLG.

*Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint-Petersburg, Russia;

Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia;

Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint-Petersburg, Russia;

§Department of Histopathology, King Edward Memorial Hospital, Perth, Australia;

Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic;

Department of Dermatology, Medical Military Academy, Saint-Petersburg, Russia; and

**Bioptical Laboratory, Pilsen, Czech Republic.

Reprints: Dmitry V. Kazakov, MD, PhD, Sikl's Department of Pathology, Charles University Medical Faculty Hospital, Alej Svobody 80, 304 60 Pilsen, Czech Republic (e-mail:

Supported in part by the Charles University Research Fund (project number SVV-2016–260 282).

The authors declare no conflicts of interest.

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