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Connective Tissue Nevi

A Review of the Literature

Arora, Harleen BS*; Falto-Aizpurua, Leyre MD; Cortés-Fernandez, Andrea MD; Choudhary, Sonal MD§,‖; Romanelli, Paolo MD

The American Journal of Dermatopathology: May 2017 - Volume 39 - Issue 5 - p 325–341
doi: 10.1097/DAD.0000000000000638
CME Article

Abstract: Connective tissue nevi (CTN) are hamartomas of the dermis, with the 3 main components being collagen, elastin, and proteoglycans. Each subtype can present as a solitary lesion or multiple lesions. They could present as part of systemic diseases or inherited disorders. This article provides a comprehensive literature review of the different types of CTN, their clinical presentations, associations, and treatment options. Treatment options for 56 lesions were reviewed. Fifty-two percent of lesions were present in males, and the age range at the time of presentation was wide (1.6–80 years). Management varied according to CTN subtypes. Most lesions (14) received topical or intralesional treatment with corticosteroids, followed by surgical removal of lesions (12), whereas the remaining lesions were clinically monitored.

*Medical Student MS3, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL;

Resident in Dermatology (PGY2), University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico;

Researcher at Genetics and Molecular Medicine Laboratory, Department of Medicine, Universidad del Norte, Barranquilla, Atlántico, Colombia;

§Department of Dermatology and

Faculty Dermatology and Dermatopathology, University of Pittsburgh Medical Center, Pittsburgh, PA; and

Professor of Dermatology and Dermatopathology, Director of Dermatopathology, University of Miami Miller School of Medicine, Miami, FL.

Reprints: Sonal Choudhary, MD, Department of Dermatology, Medical Arts Building, 3708 5th Avenue, Pittsburgh, PA 15213 (e-mail:

All authors, faculty, and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

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