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Lesions With an Epidermal Hyperplastic Pattern

Morphologic Clues in the Differential Diagnosis

Fernandez-Flores, Angel MD, PhD

The American Journal of Dermatopathology: January 2016 - Volume 38 - Issue 1 - p 1–19
doi: 10.1097/DAD.0000000000000324
CME Article

Abstract: In this report, we review the most common entities that show a epidermal hyperplastic pattern in the biopsy. These entities include inflammatory, reactive, infectious, hamartomatous, and tumoral conditions, each with a very different prognosis. Therefore, an approach based on the classic “patterns and clues” tools used in dermatopathology can bring a lot of information to the dermatopathologist or the general pathologist evaluating these lesions.

Consultant Hisopathologist, Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.

Reprints: Angel Fernandez-Flores, MD, PhD, Servicio de Anatomía Patologica, Hospital El Bierzo, Medicos sin Fronteras 7, Ponferrada 24411, Spain (e-mail:

All authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no financial relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

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