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Biclonal Chronic Lymphocytic Leukemia Presenting as Skin Lesion

Singh, Anurag MD*; Graziano, Stephen MD*; Vajpayee, Neerja MD

The American Journal of Dermatopathology: March 2014 - Volume 36 - Issue 3 - p 260–262
doi: 10.1097/DAD.0b013e3182a3326d
Brief Report

Abstract: Chronic lymphocytic leukemia (CLL) is by far the most common mature B-cell leukemia in Western countries. Some patients with CLL present with manifestations of extra medullary disease. We report a case of biclonal CLL/small lymphocytic lymphoma in an elderly patient who initially presented with skin lesions, no other systemic symptoms, and normal white cell count. Skin biopsy revealed concurrence of basal cell carcinoma and a nodular dermal infiltrate with immunophenotype consistent with CLL/small lymphocytic lymphoma. Polymerase chain reaction assay for immunoglobulin heavy chain gene rearrangement revealed the presence of 2 distinct B-cell clones in the peripheral blood. The clinicopathological characterization of this case is presented here.

Departments of *Medicine, and

Pathology, SUNY Upstate Medical University, Syracuse, NY.

Reprints: Neerja Vajpayee, MD, Department of Pathology, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210 (e-mail:

The authors declare no conflicts of interest.

© 2014 by Lippincott Williams & Wilkins.