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Multilocular Mesothelial Proliferation Involving the Skin of the Umbilicus

Konstantinova, Anastasia M. MD, PhD*,†; Michal, Michal MD‡,§; Kacerovska, Denisa MD, PhD‡,§; Kazakov, Dmitry V. MD, PhD‡,§

The American Journal of Dermatopathology: December 2013 - Volume 35 - Issue 8 - p 856–858
doi: 10.1097/DAD.0b013e3182858460
Extraordinary Case Report

Abstract: Multilocular mesothelial proliferation (MMP) is a rare lesion that mainly arises from the peritoneal mesothelium. Most often, it occurs in women of reproductive age, with a history of abdominal surgery, endometriosis, or pelvic inflammatory disease. We describe an unusual case of a 73-year-old woman affected by a large MMP, which involved the skin and presented clinically as a cutaneous mass. To the best of our knowledge, MMP involving the umbilicus has never been reported in a peer-reviewed literature.

*Department of Pathology, Clinical Oncological Scientific and Practical Centre for Specialized Medical Care, Saint-Petersburg, Russia;

Medical Department, Saint-Petersburg State University, Saint-Petersburg, Russia;

Sikl's Department of Pathology, Charles University in Prague, Faculty of Medicine in Pilsen, Pilsen, Czech Republic;

§Bioptical Laboratory, Pilsen, Czech Republic.

The authors declare no conflicts of interest.

Reprints: Dmitry V. Kazakov, MD, PhD Sikl's Department of Pathology, Charles University Medical Faculty Hospital, Alej Svobody 80, 304 60 Pilsen, Czech Republic (e-mail:

© 2013 by Lippincott Williams & Wilkins.