Brief ReportA Rare Case of Granuloma Annulare in a 5-Year-Old Child With Type 1 Diabetes and Autoimmune ThyroiditisMaschio, Maddalena MD*; Marigliano, Marco MD*; Sabbion, Alberto MD*; Morandi, Anita MD*; Schena, Donatella MD†; Colato, Chiara MD‡; Maffeis, Claudio MD*Author Information *Regional Center for Pediatric Diabetes, Clinical Nutrition & Obesity, Department of Life & Reproduction Sciences, University of Verona, Verona, Italy †Department of Medicine, Unit of Dermatology and Venereology, University of Verona, Verona, Italy ‡Department of Pathology and Diagnostics, Section Pathology, University of Verona, Verona, Italy. Reprints: Marco Marigliano, MD, Unit of Pediatric Diabetes, Clinical Nutrition and Obesity, Department of Life and Reproduction Sciences, University of Verona, Via Bengasi 4, Verona 37134, Italy (e-mail: [email protected]). This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector. The authors declare no conflicts of interest. The American Journal of Dermatopathology: May 2013 - Volume 35 - Issue 3 - p 385-387 doi: 10.1097/DAD.0b013e318272f6c6 Buy Metrics Abstract Granuloma annulare (GA) has rarely been reported in childhood, and its etiology still remains unclear. Its association with type 1 diabetes (T1D) and other chronic systemic diseases such as autoimmune thyroiditis (AT) or rheumatoid arthritis has been reported. There is no description in the literature of pediatric cases and the simultaneous association of GA and multiple autoimmune diseases in the same subject. We report the case of a 5-year-old girl who presented onset signs and symptoms of T1D. The diagnosis of T1D was confirmed by the presence of autoimmune T1D antibodies. Moreover, AT was also diagnosed by autoantibodies and positive ultrasound. One month later, coin-size erythematous lesions appeared initially on the trunk but soon spread over the body. Once dermatophytosis had been excluded, a skin biopsy confirmed a diagnosis of GA. Although a clear mechanism remains still unknown, clinicians must take into consideration an association of GA in patients with T1D or AT to avoid unnecessary medical investigations and/or inadequate pharmacological treatment. © 2013 by Lippincott Williams & Wilkins.