Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Signet-Ring Cell/Histiocytoid Carcinoma of the Eyelid

A Case Report and Review of the Literature

Tanboon, Jantima, MD*; Uiprasertkul, Monkol, MD*; Luemsamran, Panitee, MD

The American Journal of Dermatopathology: February 2013 - Volume 35 - Issue 1 - p e1–e5
doi: 10.1097/DAD.0b013e318264991c
Extraordinary Case Report

Abstract: Signet-ring cell/histiocytoid carcinomas of the eyelid are rare, slow-growing, and locally aggressive tumors. They predominantly affect elderly men and clinically resemble chronic inflammatory process such as blepharitis and chalazion. To date, the histogenesis of the tumors is still controversial. Only 27 cases of primary signet-ring cell/histiocytoid carcinomas of the eyelid are published in the literature. Local recurrence and distant metastasis occur in 8 and 7 cases, respectively. We report clinical, radiographic, and pathological features of a case of signet-ring cell/histiocytoid carcinoma of the eyelid with review of relevant literature.

Departments of *Pathology

Ophthalmology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Reprints: Jantima Tanboon, MD, Department of Pathology, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand (e-mail:

The authors declare no conflicts of interest.

© 2013 by Lippincott Williams & Wilkins.