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Expression of Matrix Metalloproteinase-13 and Ki-67 in Nonmelanoma Skin Cancer in Xeroderma Pigmentosum and Non-xeroderma Pigmentosum

El-Hawary, Amira K., PhD*; Yassin, Eman, PhD*; Khater, Ashraf, PhD; Abdelgaber, Soheir, PhD

The American Journal of Dermatopathology: February 2013 - Volume 35 - Issue 1 - p 45–49
doi: 10.1097/DAD.0b013e31825aa334
Original Study
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Abstract: Xeroderma pigmentosum (XP) is a heterogenous group of genetic diseases in which basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer (NMSC) followed by squamous cell carcinoma (SCC). The aim of this study was to investigate the expression of matrix metalloproteinase (MMP)-13 and Ki-67 in SCC and BCC from patients with and without XP to elucidate their roles in the pathogenesis of these highly aggressive tumors in patients with XP. Immunolabeling using MMP-13 and Ki-67 antibodies was performed on tissue sections derived from skin biopsies of SCC and BCC of 15 patients with XP and 40 non-XP patients. There was no significant difference between XP and non-XP patients as regards MMP-13 expression by epithelial and stromal cells of SCC or BCC. Ki-67 expression in SCC and BCC of patients with XP was significantly higher than in non-XP patients. We concluded that the higher expression of Ki-67 in NMSC of patients with XP than of non-XP patients may reflect the growth and invasive capacity of these tumors in patients with XP. MMP-13 is expressed by tumor epithelial cells, stromal and inflammatory cells of NMSC of both XP and non-XP patients.

*Department of Pathology

Mansoura Oncology Center

Department of Dermatology and Andrology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Reprints: Amira K. El-Hawary, PhD, Pathology Department, Faculty of Medicine, Mansoura University, 2 El-Gomhouria Street, Mansoura 35516, Egypt (e-mail: amira960@hotmail.com).

The authors declare no conflicts of interest.

© 2013 by Lippincott Williams & Wilkins.