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Spectrum of Cutaneous and Soft Tissue Lesions in Two Carney Complex Patients—Adnexal Induction Versus Authentic Adnexal Neoplasms

Kacerovska, Denisa MD, PhD*,†; Requena, Luis MD; Michal, Michal MD*,†; Grossmann, Petr RNDr; Treskova, Inka MD§; Roucka, Patrik MD; Kazakov, Dmitry V. MD, PhD*,†

The American Journal of Dermatopathology: October 2012 - Volume 34 - Issue 7 - p 729–736
doi: 10.1097/DAD.0b013e31824d1165
Original Study

Abstract: Two unusual Carney complex patients are described. In one of them, several cutaneous biopsies revealed myxoid lesions that were rather more close to authentic adnexal neoplasms with myxoid stroma than to a “myxoma with an epithelial component.” These included lesions resembling trichofolliculoma, infundibular cyst, and trichodiscoma. Additionally, 1 soft tissue myxoma was unique in the sense that it greatly resembled a cardiac myxoma, begging the question whether this could represent an embolus from the patient's cardiac myxoma. Given the large size and complexity and heterogeneity of the cutaneous lesions, the authors suggest that these may represent authentic cutaneous neoplasms accompanied by myxoid stroma and not adnexal elements induced by the stroma. However, the latter mechanism is well recognized and demonstrated by our second patient in whom adnexal-type elements in the cutaneous lesion were clearly induced by the myxoid stroma but were unusually complex by manifesting panfollicular and also sebaceous differentiation.

*Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic

Bioptical Laboratory, Pilsen, Czech Republic

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain

§Department of Plastic Surgery, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic

Department of Cardiosurgery, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic.

Reprints: Dmitry. V. Kazakov, MD, PhD, Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Alej Svobody 80, 304 60, Pilsen, Czech Republic (e-mail:

The authors declares no conflicts of interest.

© 2012 Lippincott Williams & Wilkins, Inc.