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Myxoinflammatory Fibroblastic Sarcoma of the Face

Gómez Martín, Cristina MD*; Ortega, María I. MD*; Aramburu, José A. MD; Fernández-Cañamaque, José L. MD*

The American Journal of Dermatopathology: August 2012 - Volume 34 - Issue 6 - p 663–665
doi: 10.1097/DAD.0b013e31824e9a28
Extraordinary Case Report

Abstract: Myxoinflammatory fibroblastic sarcoma (MIFS) is a rare low-grade tumor of modified fibroblasts, with tendency to local recurrence. This unusual entity typically presents as a slow-growing painless mass in the distal extremities of middle-aged subjects. A 48-year-old woman presented to our clinic with a painless subcutaneous mass in the right temporal region. Excisional biopsy made the rare diagnosis of MIFS. Histologic examination showed the unique features that characterize this lesion: a myxoid component with a superimposed inflammatory infiltrate and the presence of distinctive, large, and bizarre Reed-Stemberg–like cells. A second wide tumor bed resection was performed, achieving clear margins. No adjuvant therapy was administered, and the patient is free of disease at 18 months postoperatively. To the best of our knowledge, this is the first reported case of MIFS presenting in the face. This adds another possibility for differential diagnoses of soft tissue tumors of the face.

*Department of Plastic and Reconstructive Surgery, Hospital Universitario de Getafe, Madrid, Spain

Department of Pathology, Hospital Universitario de Getafe, Madrid, Spain.

Reprints: Cristina Gómez, MD, Department of Plastic and Reconstructive Surgery and Burn Unit, Hospital Universitario de Getafe, Carretera de, Toledo, Km. 12.5, 28905 Getafe, Madrid, Spain (e-mail:

Funding sources: none.

None of the authors have any conflict of interest to disclose in association with this article.

© 2012 Lippincott Williams & Wilkins, Inc.