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A Study of Histopathologic Spectrum of Nodular Hidradenoma

Nandeesh, Bevinahalli N. MD, DNB*; Rajalakshmi, T. MD, DNB

The American Journal of Dermatopathology: July 2012 - Volume 34 - Issue 5 - p 461–470
doi: 10.1097/DAD.0b013e31821a4d33
CME Article

Background: Hidradenomas are rare benign adnexal neoplasms that encompass a morphological gamut with a range of differentiation. As a consequence, there is a great likelihood of being mistaken for other primary and metastatic tumors. Though conventionally regarded as eccrine, they have been reclassified into eccrine and apocrine types.

Objective: This study aims to document the histological spectrum of nodular hidradenomas, with particular reference to categorizing them into eccrine or apocrine tumors.

Results: A total of 15 cases with features of nodular hidradenoma with their age ranging from 18 years to 73 years were studied. Most of the cases were solitary, circumscribed, solid and cystic, dermal, symmetrical, lobulated tumors with a sheet-like and papillary architecture. The cells were chiefly eosinophilic with a regular oval grooved nucleus and a small inconspicuous nucleolus. Clear cells were also seen. Squamous differentiation was an important feature, with most showing a infundibular type of keratinization. Sebaceous differentiation is also common. The stroma varied from hyaline to myxoid. Only 1 case showed poroid differentiation.

Conclusions: This study describes the assortment of histologic characteristics in hidradenomas. Apocrine hidradenomas are more common, contrary to earlier belief that favored an eccrine origin.

*Assistant Professor

Associate Professor, Department of Pathology, St John's Medical College, Bangalore, India.

The authors and staff in a position to control the content of this CME activity and their spouses/life partners (if any) have disclosed that they have no relationships with, or financial interests in, any commercial organizations pertaining to this educational activity.

Reprints: Dr B.N. Nandeesh, MD, DNB, Assistant Professor, Department of Pathology, St John's Medical College, Bangalore 560034, India (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.