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Considerations on the Performance of Immunohistochemistry for Mismatch Repair Gene Proteins in Cases of Sebaceous Neoplasms and Keratoacanthomas With Reference to Muir–Torre Syndrome

Fernandez-Flores, Angel MD, PhD

The American Journal of Dermatopathology: June 2012 - Volume 34 - Issue 4 - p 416–422
doi: 10.1097/DAD.0b013e3182226a28
Review Article

Abstract: Cutaneous sebaceous tumors, as well as keratoacanthomas, are associated with Muir–Torre syndrome (MTS). Visceral neoplasias are a feature of this syndrome; thus, early detection using a cutaneous biopsy is very important in dermatopathology. A dermatopathologist can apply different techniques in such cases, including immunohistochemistry for several mismatch repair proteins or molecular studies for microsatellites instability. However, in a world where economic resources play an increasing role, how discriminative the dermatopathologist should be in investigating cutaneous lesions that may indicate MTS is not a trivial matter. Although previous reports have presented algorithms on MTS focusing on a multidisciplinary approach, our report emphasizes the role of the dermatopathologist and tries to answer several questions that could arise when facing a cutaneous tumor that may indicate MTS.

Department of Anatomic Pathology, Hospital El Bierzo, Ponferrada, Spain.

The authors report no conflicts of interest to declare.

Reprints: Angel Fernandez-Flores, MD, PhD, Servicio de Anatomia Patológica, Hospital El Bierzo, C/ Médicos sin Fronteras 7, 24411, Fuentesnuevas, Leon, Spain (e-mail:

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.