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Mucocutaneous Pseudoepitheliomatous Hyperplasia: A Review

El-Khoury, Jinane MD; Kibbi, Abdul-Ghani MD; Abbas, Ossama MD

The American Journal of Dermatopathology: April 2012 - Volume 34 - Issue 2 - p 165–175
doi: 10.1097/DAD.0b013e31821816ab
Review Article

Pseudoepitheliomatous hyperplasia, also called pseudocarcinomatous hyperplasia because of its resemblance to well-differentiated squamous cell carcinoma, is a reactive epithelial proliferation that is characterized by prominent irregular hyperplasia of the epithelium with tongue-like epithelial projections into the dermis. This reactive pattern may involve cutaneous or mucosal surfaces and has been described in association with a wide variety of stimuli including infectious, neoplastic, inflammatory, and traumatic among others. In this review, we will discuss the pathophysiology of pseudoepitheliomatous hyperplasia, the histopathological findings that are helpful in its differentiation from squamous cell carcinoma, and the spectrum of conditions that may show this unique feature on microscopic examination.

Dermatology Department, American University of Beirut Medical Center, Beirut, Lebanon.

The authors have no funding or conflicts of interest to disclose.

Reprints: Ossama Abbas, MD, Assistant Professor, Department of Dermatology, American University of Beirut Medical Center, Riad El Solh/Beirut 1107 2020, Beirut, Lebanon (e-mail:

© 2012 Lippincott Williams & Wilkins, Inc.