Brief ReportEpstein-Barr Virus–Associated Smooth Muscle Tumor Mimicking Cutaneous AngioleiomyomaPetersson, Fredrik MD, PhD; Huang, Jingxiang MD, PhDAuthor Information From the Department of Pathology, National University Health System, Singapore. Reprints: Fredrik Petersson, MD, PhD, Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074 (e-mail: [email protected]). The American Journal of Dermatopathology: June 2011 - Volume 33 - Issue 4 - p 407-409 doi: 10.1097/DAD.0b013e3181ed5fd9 Buy Metrics Abstract We present a case of a subcutaneous, unifocal, Epstein-Barr virus-associated smooth muscle tumor mimicking a cutaneous angioleiomyoma. The patient was immunocompromised due to a renal transplant. The tumor displayed diffuse and strong immunoreactivity for smooth muscle actin, H-caldesmon; focal positivity for desmin; and strong and diffuse positivity for Epstein-Barr virus RNA on in situ hybridization. This unique presentation emphasizes the importance of considering this pathologic entity when solitary smooth muscle tumors with the histological features of an angioleiomyoma are encountered in immunocompromised patients. © 2011 Lippincott Williams & Wilkins, Inc.