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Metastatic Hürthle Cell Carcinoma of the Thyroid Presenting as Ulcerated Scrotum Nodules

Shon, Wonwoo DO; Ferguson, Sara B MD; Comfere, Nneka I MD

The American Journal of Dermatopathology: June 2010 - Volume 32 - Issue 4 - p 392-394
doi: 10.1097/DAD.0b013e3181c1acaf
Extraordinary Case Report

Cutaneous metastasis from Hürthle cell carcinoma of the thyroid is an extremely rare phenomenon. As far as we can determine, there has been only a single case documented. Our patient, a 68-year-old man with a history of Hürthle cell carcinoma of the thyroid, had cutaneous nodules in the scrotum and right chin. Histologic and immunohistochemical examinations confirmed the diagnosis of metastatic Hürthle cell carcinoma of the thyroid. To the best of our knowledge, this is the first reported case of scrotal skin metastasis. This case emphasizes the importance of thorough clinicopathologic correlation for any patient with a malignant scrotal cutaneous neoplasm with Hürthle cell or oncocytic differentiation.

From the *Department of Laboratory Medicine and Pathology, Division of Anatomic Pathology; and †Department of Dermatology, Mayo Clinic, Rochester, MN.

Funding sources: None.

Conflicts of interest: The authors have no conflict of interest to declare.

Reprints: Nneka I. Comfere, MD, Department of Dermatology, Mayo Clinic, 200 First Street Southwest, Rochester, MN, 55905 (e-mail:

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