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Free-Floating Collagen Fibers in Interstitial Mycosis Fungoides

Ferrara, Gerardo MD; Crisman, Giuliana MD; Zalaudek, Iris MD; Argenziano, Giuseppe MD; Stefanato, Catherine M MD, FRCpath

The American Journal of Dermatopathology: June 2010 - Volume 32 - Issue 4 - p 352-356
doi: 10.1097/DAD.0b013e3181b876d7
Brief Report

We present a case of interstitial mycosis fungoides showing pseudodovascular clefts with “free-floating” collagen fibers surrounded by neoplastic T lymphocytes. Such a finding further expands the histopathologic spectrum of mycosis fungoides and could be taken into account in its differential diagnosis from granuloma annulare, inflammatory morphea, and interstitial granulomatous drug reaction.

From the *Anatomic Pathology Unit Gaetano Rummo General Hospital, Benevento, Italy; †Department of Dermatology, University of Trieste, Trieste, Italy; ‡Department of Dermatology, Medical University of Graz, Graz, Austria; §Department of Dermatology, Second University of Naples, Naples, Italy; and ¶Department of Dermatopathology, St. John's Institute of Dermatology, St. Thomas' Hospital, London, UK.

Conflict of interest: none to be declared.

Reprints: Gerardo Ferrara, MD, Department of Oncology, Pathologic Anatomy Unit, Gaetano Rummo General Hospital, Via dell'Angelo 1, I-82100 Benevento, Italy (e-mail:

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