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Basal Cell Carcinoma-Associated Paratumoral Follicular and Epidermal Hyperplasia

Abenoza, Pascual MD; Kowalczyk, John BBA; Nousari, Carlos H MD

The American Journal of Dermatopathology: June 2010 - Volume 32 - Issue 4 - p 348-351
doi: 10.1097/DAD.0b013e3181b84ed6
Original Study

Reactive epithelial hyperplasia is a well-known phenomenon which occurs adjacent to certain neoplasms such as cutaneous fibrous histiocytoma, granular cell tumor, Spitz nevus, and melanoma. We report 46 cases of paratumoral follicular and epidermal hyperplasia associated with basal cell carcinoma (BCC). This reactive process associated with BCC has certain characteristic features. It is focal, superficial, and predominantly folliculocentric. It may resemble other tumors such as squamous cell carcinoma and may appear in sections where BCC is absent. The recognition of this entity may help dermatopathologists avoid misdiagnosing this process as a tumor and can suggest further search (section through the block or rebiopsy) when this reactive phenomenon is seen in sections without the associated BCC.

From the *Dermpath Diagnostics South Florida, Pompano Beach, FL; †University of Miami L. Miller School of Medicine, Department of Dermatology, Miami, FL; and ‡University of Miami, Department of Dermatology, Institute of Immunofluorescence, Dermpath Diagnostics South Florida, FL.

Reprints: Carlos H. Nousari, MD, Institute of Immunofluorescence, Dermpath Diagnostics South Florida, 895 S.W. 30th Avenue, suite 101, Pompano Beach, FL 33069 (e-mail:

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