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Acantholytic-Like Malignant Melanoma: An Unusual Morphologic Variant

Aneiros-Fernández, Jose MD; Arias-Santiago, Salvador MD; Diaz-Recuero, Jose Luis MD; O'Valle Ravassa, Francisco PhD; Nogales Fernández, Francisco PhD; Aneiros Cachaza, Jose PhD

The American Journal of Dermatopathology: June 2010 - Volume 32 - Issue 4 - p 364-366
doi: 10.1097/DAD.0b013e3181bad002
Extraordinary Case Report

We report the case of a primary cutaneous melanoma with acantholytic-like changes in a 61-year-old man. Clinical and immunohistochemic features were similar to those of other superficial spreading with vertical growth melanomas. Histologically, intraepidermal and suprabasal bullous spaces were filled by isolated tumor cells, simulating acantholytic blisters. These findings could be explained by the presence of inflammation-related extracellular fluid. Two other cases with suprabasal discohesive atypical melanocytes have recently been described. We report the first case of malignant melanoma with an intense and diffuse pattern of dyscohesion, resembling acantholysis. Recognition of this histologic pattern in malignant melanoma is important to avoid a misdiagnosis.

From the *Departments of Pathology; and †Dermatology, San Cecilio University Hospital, Granada, Spain.

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