Critical ReviewViral-Associated Nonmelanoma Skin Cancers: A ReviewDubina, Meghan MD*; Goldenberg, Gary MD†Author Information From the *Department of Internal Medicine, University of Maryland School of Medicine, Baltimore, MD; and †Department of Dermatology, Mount Sinai School of Medicine, New York, NY. Conflicts of interest: none Reprints: Gary Goldenberg, MD, Assistant Professor, Department of Dermatology, Mount Sinai School of Medicine, 1425 Madison Avenue L2-21, New York, NY 10029 (e-mail: [email protected]). The American Journal of Dermatopathology: August 2009 - Volume 31 - Issue 6 - p 561-573 doi: 10.1097/DAD.0b013e3181a58234 Buy Metrics Abstract Nonmelanoma skin cancers are the most common malignancies in the United States, with over 1.3 million patients diagnosed yearly. Several types of nonmelanoma skin cancer and precancerous lesions have an associated viral pathogenesis, including epidermodysplasia verruciformis, verrucous carcinoma, bowenoid papulosis, Kaposi sarcoma, squamous cell carcinoma, and, most recently, Merkel cell carcinoma. It is now widely accepted that high-risk human papillomaviruses (HPVs) play a key role in pathogenesis of cervical and anogenital cancer. Currently, 108 types of HPV have been discovered. They can be divided into genera including alpha, beta, and gamma HPVs, which comprise the majority of cutaneous HPVs. The relationship between viruses and cancer is a popular focus of research in an era of AIDS and organ transplantation, where immunosuppression is not uncommon. The incidence of viral-related malignancies in these populations is increasing. Because of the widespread nature of these cutaneous malignancies, an evaluation of these conditions is valuable. This review of the literature will focus on the histologic aspects of viral-associated skin malignancies, as well as the epidemiology, etiology, and clinical aspects of these diseases. © 2009 Lippincott Williams & Wilkins, Inc.