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An Unusual Squamo-melanocytic Tumor of Uncertain Biologic Behavior: A Variant of Melanoma?

Pouryazdanparast, Pedram MD*; Yu, Limin MD*; Johnson, Timothy MD†‡§; Fullen, Douglas MD*†

The American Journal of Dermatopathology: July 2009 - Volume 31 - Issue 5 - p 457-461
doi: 10.1097/DAD.0b013e318182c7dc
Extraordinary Case Report

The presence of two intermingled malignant components within the same cutaneous tumor is rare. Herein, we report a case of an exceedingly rare squamo-melanocytic tumor, favored to be a melanoma variant. Although the biologic behavior and prognostic significance of this tumor remain to be established, this unique case reaffirms the potential morphologic diversity of melanoma. We review the literature reporting similar neoplasms and discuss the potential histogenesis of this squamo-melanocytic tumor.

From the Departments of *Pathology; †Dermatology; ‡Otolaryngology; and §Surgery, University of Michigan, Ann Arbor, MI.

Funding: None.

Conflict of interest: None.

Reprints: Douglas R. Fullen, MD, M3261, Medical Science I, Department of Pathology, University of Michigan Medical Center, 1301 Catherine, Ann Arbor, MI 48109-0602, USA (e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.