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Human Papillomavirus-58 and -73-Associated Digital Squamous Cell Carcinoma in a Patient With Aggressive Digital Papillary Adenocarcinoma

DePond, William MD*; Kure, Kiyoe MD, PhD*; Lankachandra, Kamani MD*; Gidwani, Raja MD*; Nelson, Brook V MD; Zimmerman, Hannah MD; Talboy, Glenn E Jr MD; Miranda, Roberto N MD*

The American Journal of Dermatopathology: June 2009 - Volume 31 - Issue 4 - p 375-378
doi: 10.1097/DAD.0b013e31818a5c37
Extraordinary Case Report

Aggressive digital papillary adenocarcinoma (ADPA) is a rare tumor that is considered to arise from eccrine sweat glands of the skin. It occurs predominantly in men with a mean age in the sixth decade. It shows a strong tendency for local recurrence and has the potential to metastasize to distant sites. Prompt diagnosis and regular follow-up are important to ensure the best possible outcome. We discuss a case of recurrent ADPA associated with subsequent squamous cell carcinoma (SCC) in different contralateral digits in a 55-year-old man. One SCC lesion tested positive for human papillomavirus (HPV)-58. HPV-associated digital SCCs have been reported; most cases are HPV-16 positive. This report describes a rare case of an HPV-58-positive invasive digital SCC and an HPV-73-positive SCC in situ associated with ADPA.

From the *Department of Pathology; †Surgery, University of Missouri-Kansas City, School of Medicine, Truman Medical Center, Kansas City, MO; and ‡University of Arizona.

Reprints: Kiyoe Kure, MD, PhD, Department of Pathology, Truman Medical Center, 2301 Holmes Street, Kansas City, MO 64108 (e-mail:

© 2009 Lippincott Williams & Wilkins, Inc.