Extraordinary Case ReportEccrine Syringofibroadenoma Associated With Well-Differentiated Squamous Cell CarcinomaKacerovska, Denisa MD, PhD; Nemcova, Jana MSc; Michal, Michal MD; Kazakov, Dmitry V MD, PhDAuthor Information From the Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Pilsen, Czech Republic. Reprints: Dmitry V. Kazakov, MD, PhD, Sikl's Department of Pathology, Charles University, Medical Faculty Hospital, Alej Svobody 80, 304 60 Pilsen, Czech Republic (e-mail: [email protected]). The American Journal of Dermatopathology: December 2008 - Volume 30 - Issue 6 - p 572-574 doi: 10.1097/DAD.0b013e31817d4c90 Buy Metrics Abstract We report a case of an eccrine syringofibroadenoma (ESFA) associated with well-differentiated squamous cell carcinoma. The patient was an 85-year-old man, who had a 2.5 × 2.5-cm, brown-colored ulcerated nodule, with a fragile, flesh-colored bleeding surface located beyond the metacarpophalangeal joint of the second finger of his left hand. Histopathologically, there were areas of a well-differentiated squamous cell carcinoma, alternating with the typical area of ESFA characterized by anastomosing cords, strands, and columns of epithelial cells extending from the crusted epidermis into a thickened, edematous, myxoid vascular-rich dermis. Immunohistochemically, the areas with dysplastic epithelium were positive for p16, whereas the benign ESFA parts tested negative. Human papillomavirus was detected in the lesional tissue by polymerase chain reaction, and the subsequent sequencing analysis demonstrated that the virus was close to human papillomavirus type 107. © 2008 Lippincott Williams & Wilkins, Inc.