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Oral Lichenoid Lesions in HIV-HCV-Coinfected Subjects During Antiviral Therapy: 2 Cases and Review of the Literature

Giuliani, Michele MD, DDS*; Lajolo, Carlo PhD, MD, DDS*; Sartorio, Alessandra DDS*; Scivetti, Michele DDS, PhD; Capodiferro, Saverio DDS; Tumbarello, Mario MD

The American Journal of Dermatopathology: October 2008 - Volume 30 - Issue 5 - p 466-471
doi: 10.1097/DAD.0b013e31817e23af
Extraordinary Case Report

Some dental materials and certain drugs may induce epithelial alterations, which clinically resemble oral lichen planus (OLP), on oral mucosa. But these alterations do not have all the clinical and/or the histological features of OLP; these lesions are known as oral lichenoid lesions (OLLs). Some researchers describe the onset and/or the worsening of OLL/OLP after the administration of anti-hepatitis C virus (HCV) therapy. In this article, we describe the development of symptomatic OLLs, as a consequence of anti-HCV therapy (interferon-α and ribavirine), in 2 human immunodeficiency virus-HCV-coinfected subjects. An immunological cause related to coinfection and administration of different medications could be responsible for the onset of OLLs. These new cases, together with the previous reports of a possible association between OLP and/or OLL and anti-HCV therapy, highlight the absolute need to monitor carefully the human immunodeficiency virus-HCV-coinfected subjects who are about to start the anti-HCV therapy and to define better the clinical and histopathological criteria to distinguish OLP from OLL.

From the *School of Dentistry, Catholic University, Rome, Italy; †School of Dentistry, Università degli Studi di Bari, Bari, Italy; and ‡Institute of Infectious Diseases, Catholic University, Rome, Italy.

Reprints: Dr. Michele Giuliani, MD, DDS, School of Dentistry, Catholic University, Largo A. Gemelli, 8, 00168 Rome, Italy (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.