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Cutaneous Epithelioid Angiomatous Nodule: A Case Series and Proposed Classification

Sangüeza, Omar P MD*; Walsh, Sarah N MD*; Sheehan, Daniel J MD*; Orland, Almudena Fernández MD*; Llombart, Beatriz MD; Requena, Luis MD

The American Journal of Dermatopathology: February 2008 - Volume 30 - Issue 1 - p 16-20
doi: 10.1097/DAD.0b013e31815f2b07
Original Article

Cutaneous epithelioid angiomatous nodule is a peculiar and recently recognized vascular proliferation. Clinically, these lesions affect different areas of the body and histologically are characterized by a well-circumscribed, mainly unilobular, solid proliferation of endothelial cells with prominent epithelioid features. The cytoplasm is abundant and eosinophilic, and many of the neoplastic cells contain prominent vacuoles. Inflammatory infiltrates are variable. All the cases reported thus far have followed a benign course. We report 10 additional cases of this curious entity, including 2 which presented in an eruptive fashion and 5 that were located on the head and neck. We also discuss the histological differential diagnoses with other epithelioid proliferations and propose categorization within the spectrum of epithelioid hemangioma.

From the *Departments of Dermatology and Pathology, Wake Forest University School of Medicine, Winston-Salem, NC; †Instituto Valenciano Oncologia, Valencia, Spain; and ‡Department of Dermatology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain.

The authors received no financial support for this work.

Reprints: Omar P. Sangüeza, MD, Professor and Director of Dermatopathology, Departments of Dermatology and Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1072 (e-mail:

© 2008 Lippincott Williams & Wilkins, Inc.