Extraordinary Case ReportAngiolymphoid Hyperplasia With Eosinophilia Showing Prominent Granulomatous and Fibrotic Reaction: A Morphological and Immunohistochemical StudyMacarenco, Ricardo S MD*; do Canto, Abaetê Leite MD*; Gonzalez, Sergio MD†Author Information From the *CIPAX-Surgical Pathology and Cytopathology Institute, Sao Jose dos Campos, Sao Paulo State-Brazil; and †Department of Pathology, Catholic University of Chile, School of Medicine, Santiago-Chile. Reprints: Ricardo S. Macarenco, MD, Rua Jose Pulga, 91 Ap 86. JD Aquarius. Sao Jose dos Campos (SP)-Brazil. CEP 12243-022 Brazil (e-mail: [email protected]). The American Journal of Dermatopathology: December 2006 - Volume 28 - Issue 6 - p 514-517 doi: 10.1097/01.dad.0000211505.21995.a1 Buy Metrics Abstract Angiolymphoid hyperplasia with eosinophilia is an uncommon condition that usually presents in early to middle-aged adults as multiple red nodules or plaques, most commonly on the head and neck. It can also occur on the trunk and limbs, and rarely at other sites such as the breast and oral mucosa. Although one-third of these lesions recur, surgical excision is curative. The histopathological hallmark is the presence of blood vessels with plump epithelioid endothelial cells. The nonvascular component consists of histiocytes, plasma cells, eosinophils, and lymphocytes. The occurrence of numerous giant cells in the stroma of angiolymphoid hyperplasia with eosinophilia is extremely unusual and such a finding in association with diffuse granulomatous/fibrous reaction has not been reported. We describe such a lesion that developed in the wrist of a 34-year-old pregnant female. © 2006 Lippincott Williams & Wilkins, Inc.