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Immunohistochemical Distinction Between Merkel Cell Carcinoma and Small Cell Carcinoma of the Lung

Bobos, Mattheos MD; Hytiroglou, Prodromos MD; Kostopoulos, Ioannis MD; Karkavelas, Georgios MD; Papadimitriou, Constantine S. MD

The American Journal of Dermatopathology: April 2006 - Volume 28 - Issue 2 - p 99-104
doi: 10.1097/
Original Articles

We assessed the usefulness of several immunohistochemical stains in distinguishing these two neoplasms, including cytokeratin 7, cytokeratin 20 (CK20), neuron-specific enolase, chromogranin, synaptophysin, neurofilaments (NF), thyroid-transcription factor-1 (TTF-1), CD56 antigen, S-100 protein, vimentin, c-erbB-2 oncoprotein, and CD117 antigen. All 13 cases of Merkel cell carcinoma evaluated were positive for CK20, and negative for TTF-1. Twelve of 13 Merkel cell carcinoma cases were positive for NF. Eleven of 13 cases of small cell lung carcinoma were positive for TTF-1. All small cell lung carcinoma cases were negative for NF, and all but one were negative for CK20. In terms of the remaining antigens, there were no differences of significance between the two neoplasms. These findings suggest that a set of three immunohistochemical stains, including CK20, NF, and TTF-1, is useful in affording a distinction between Merkel cell carcinoma and small cell lung carcinoma.

Department of Pathology, Aristotle University Medical School, Thessaloniki, Greece

Reprints: Prodromos Hytiroglou, Department of Pathology, Aristotle University Medical School, 540 06 Thessaloniki, Greece (e-mail:

© 2006 Lippincott Williams & Wilkins, Inc.