Sebaceoma and Related Neoplasms With Sebaceous Differentiation: A Clinicopathologic Study of 30 CasesMisago, Noriyuki M.D.; Mihara, Ichiro M.D.; Ansai, Shin-ichi M.D.; Narisawa, Yutaka M.D.The American Journal of Dermatopathology: August 2002 - Volume 24 - Issue 4 - p 294-304 Original Articles Abstract Author Information The classification of benign sebaceous neoplasms has been challenged both by the assertion that sebaceous adenomas are really carcinomas and by difficulties in drawing the boundaries between sebaceomas and other lesions. We performed a clinicopathologic study of 30 cases of basaloid neoplasms with sebaceous differentiation, excluding cases of definite sebaceous carcinoma with severe nuclear atypia invading deep within the subcutaneous tissue and those of ocular sebaceous carcinoma. We tried to classify sebaceous neoplasms in six categories with defined histopathologic criteria. All the neoplasms were characterized by aggregations of basaloid cells admixed with sebocytes and sebaceous duct-like structures located in the dermis with or without connection to the epidermis. The categories were 1) sebaceoma (14 cases); 2) trichoblastoma with sebaceous differentiation (3 cases); 3) apocrine poroma with sebaceous differentiation (2 cases); 4) low-grade sebaceous carcinoma (6 cases); 5) sebaceous carcinoma (4 cases); and 6) basal cell carcinoma with sebaceous differentiation (1 case). The sebaceoma was further subclassified as classic type (12 cases) or verruca/seborrheic keratosis type (2 cases). Although most sebaceomas can be distinguished from other lesions, there are problematic cases. We discuss the histopathologic diagnostic problems associated with sebaceoma and also argue in favor of the concept of sebaceous adenoma. From the Division of Dermatology, Department of Internal Medicine (N.M., Y.N.), Saga Medical School, Saga; Mihara Clinic of Dermatology (I.M.), Tsuruoka; and the Department of Dermatology (S.A.), Akita University School of Medicine, Akita, Japan. Address correspondence and reprint requests to Noriyuki Misago, M.D., Division of Dermatology, Department of Internal Medicine, Saga Medical School, Nabeshima 5-1-1, Saga 849-8501, Japan. E-mail: firstname.lastname@example.org © 2002 Lippincott Williams & Wilkins, Inc.