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p53 Expression in Two Cases of Spiradenocarcinomas

Fernández-Aceñero, M. J. M.D.; Manzarbeitia, F. M.D.; Mestre, M. J. B.S.; Requena, L. M.D.

The American Journal of Dermatopathology: April 2000 - Volume 22 - Issue 2 - p 104-107
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p53 protein is a nuclear 53-kDa phosphoprotein that acts as a suppressor protein. There are several studies on the expression of p53 in skin tumors, but few deal with adnexal malignant tumors because of their rarity. We performed immunohistochemistry for the detection of p53 and Ki-67 in two cases of malignant spiradenomas and six cases of spiradenomas retrieved from our files. In our cases, p53 was expressed only in the malignant areas of the lesions, whereas the benign areas of the spiradenocarcinomas and all the spiradenomas were negative (nuclear positivity <10%). These results seem to support the idea that p53 is implicated in the malignant transformation of adnexal tumors.

From the Departments of Pathology (Hospital General de Móstoles) (M.J.F.-A., M.J.M.) and Pathology (F.M.) and Dermatology (L.R.), Clínica Ntra. Sña. de la Concepción, Madrid, Spain.

Address correspondence and reprint requests to M.J. Fernández-Aceñero, M.D., C/Benito Gutiérrez 17, 4°-izda, 28008 Madrid, Spain.

© 2000 Lippincott Williams & Wilkins, Inc.