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Skin as the Primary Site of Hodgkin's Disease:: A Case Report of Primary Cutaneous Hodgkin's Disease and Review of its Relationship With Non-Hodgkin's Lymphoma

Guitart, Joan M.D.; Fretzin, David M.D.

The American Journal of Dermatopathology: April 1998 - Volume 20 - Issue 2 - p 218-222
Extraordinary Case Reviews

We report an elderly patient who presented with a single cutaneous nodule of primary cutaneous Hodgkin's disease (PCHD). Reed-Sternberg cells, expressing CD30 and CD15, but not leukocyte common antigen (CD45RB), were identified in the neoplastic cells. Southern blot analysis failed to detect T-cell receptor or immunoglobulin gene rearrangement. A work-up for systemic disease at the time of presentation was negative, supporting the diagnosis of PCHD. Nevertheless, 1 year later, the disease course was complicated by the development of nodal HD and nonHodgkin's lymphoma (NHL). This case report supports the existence of this rare, but distinct, cutaneous tumor.

From the Section of Dermatopathology, Department of Dermatology (J.G.) Northwestern University Medical Center and Department of Pathology, Michael Reese Hospital (D.F.), Chicago, Illinois, U.S.A.

Address correspondence and reprint requests to Dr. Joan Guitart at Northwestern University, 303 East Chicago Avenue (Tarry 4-711), Chicago IL 60611, U.S.A.

Presented, in part, at the Thirty-Third Annual Meeting of the American Society of Dermatopathology, Washington DC, Feb. 7-9, 1996.

© Lippincott-Raven Publishers