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Atypical Lymphoid Infiltrates Arising in Cutaneous Lesions of Connective Tissue Disease

Magro, Cynthia M. M.D.; Crowson, A. Neil M.D.; Harrist, Terence J. M.D.

The American Journal of Dermatopathology: October 1997 - Volume 19 - Issue 5 - p 446-455

Atypical lymphoid infiltrates occurring in the setting of connective-tissue disease (CTD) comprise malignant neoplasms of B-cell or T-cell phenotypes and various reactive lymphoid hyperplasias, such as myoepithelial sialadenitis, lymphocytic thyroiditis, and lymphocytic interstitial pneumonitis. We describe 17 patients with atypical lymphoid infiltrates arising in cutaneous lesions of CTD, the spectrum of which included lupus erythematosus, dermatomyositis, relapsing polychondritis, and lichen sclerosus et atrophicus. There were two principal categories, pseudolymphoma and malignant lymphoma, the former representing 15 of the 17 cases. The clinical and histologic features and possible pathogenetic mechanisms are discussed.

From the Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School Pathology Services, Inc., Cambridge, Massachusetts (C.M.M., T.J.H.); and Central Medical Laboratories and Department of Laboratories, Misericordia General Hospital, Winnipeg, Manitoba, Canada (A.N.C.).

Address correspondence and reprint requests to Dr. C.M. Magro, 640 Memorial Drive, Cambridge, MA 02139, U.S.A.

© Lippincott-Raven Publishers.