EXTRAORDINARY CASE REPORT: PDF OnlyRhinophyma's Fibrous Variant Histopathology and ImmunohistochemistryTope, Whitney D. M.Phil. M.D.; Sangueza, Omar P. M.D.Author Information From the Departments of Dermatology (W.D.T., O.P.S.) and Pathology (O.P.S.), Oregon Health Sciences University and the Veterans Administration Medical Center, Portland, Oregon. The American Journal of Dermatopathology: June 1994 - Volume 16 - Issue 3 - p 307-310 Buy Abstract Rhinophyma may present with either of two distinct histopathologic appearances. The most common shows histopathologic features of rosacea. The second pattern shows telangiectasia, diffuse dermal fibrosis with abundant mucin, and a virtual absence of pilosebaceous structures. These histopathologic features of the lesser-known fibrous variant of rhinophyma mimic those of fibrous papule of the nose. We report an unusual case that histopathologically resembled the second variant. Immunohisto-chemically, the dermal fibroblasts in this case showed intense staining with Factor XIIIa in a pattern similar to that demonstrated in fibrous papules. S-100 protein failed to stain these dermal fibroblasts. The presence of Factor XIIIa + dermal fibroblasts may portend the evolution of fibrosis in rosacea and other inflammatory dermatoses. © Lippincott-Raven Publishers.