Original Articles: GenitourinaryEvaluation of 5 Fraction Stereotactic Body Radiation Therapy (SBRT) for Osseous Renal Cell Carcinoma MetastasesDove, Austin P.H. MD*; Wells, Alex MD†; Gong, Wu MS‡; Liu, Dandan PhD‡; Kirschner, Austin N. MD, PhD* Author Information *Department of Radiation Oncology and Department of Cancer Biology ‡Department of Biostatistics †School of Medicine, Vanderbilt University Medical Center, Nashville, TN The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request. A.N.K.: conception and design. A.N.K.: development of methodology. A.W. and A.P.H.D.: acquisition of data: A.W., A.P.H.D., A.N.K., D.L., and W.G.: analysis and interpretation of data. A.W., A.P.H.D., and A.N.K.: writing, review, and/or revision of the manuscript. A.W., A.P.H.D., and A.N.K.: administrative, technical, or material support. A.N.K.: study supervision. The authors declare no conflicts of interest. Correspondence: Austin Dove, MD, Department of Radiation Oncology, 2220 Pierce Avenue, PRB-B1003, Nashville, TN 37232. E-mail: [email protected]. American Journal of Clinical Oncology: December 2022 - Volume 45 - Issue 12 - p 501-505 doi: 10.1097/COC.0000000000000952 Buy Metrics Abstract Objectives: The best fractionation for stereotactic body radiotherapy (SBRT) in renal cell carcinoma (RCC) metastases has not been well defined. In addition, the literature on outcomes using 5-fraction SBRT in the setting of osseous metastases has not been well reported. Materials and Methods: Thirty-nine patients with 69 RCC osseous metastases were treated using 5-fraction SBRT at a single institution using 2 dose-fractionation schemes. Overall survival and local-control (LC) outcomes of the 2 fractionation schemes were studied using Kaplan-Meier curves. Results: Of the 69 lesions included in the study, 20 were treated with 30 grays (Gy) in 5 fractions and 49 were treated with 40 Gy in 5 fractions. The median age of patients at diagnosis was 58.4 years. The 1-year LC rate for all treated lesions was 85.5% (59/69) with an LC of 90% (18/20) for lesions receiving 30 Gy and 83.7% (41/49) in lesions receiving 40 Gy. There was no statistically significant difference in 1-year LC rate between the 2 fractionation schemes (P-value, 0.553). Conclusions: Patients with osseous RCC metastases undergoing 5 fractions of SBRT had favorable LC outcomes. There was no difference in survival or LC between the 40 Gy and 30 Gy treatment arms. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.