Paraneoplastic Leukemoid Reaction in Solid TumorsChakraborty, Subhankar MD, PhD*; Keenportz, Brent MD†; Woodward, Suzette MD†; Anderson, Jay MD‡; Colan, David MD‡American Journal of Clinical Oncology: June 2015 - Volume 38 - Issue 3 - p 326–330 doi: 10.1097/COC.0b013e3182a530dd Review Articles Buy Abstract Author InformationAuthors Article MetricsMetrics Leukemoid reaction is defined as leucocytosis >50,000/μL. When it occurs in association with a malignancy, and infection or leukemia has been ruled out, it is termed as paraneoplastic leukemoid reaction. A patient presented with fatigue, generalized weakness, and abdominal distension and was incidentally noted to have a white blood cell count of 139,000/μL. Leukemia was ruled out by peripheral smear and flow cytometry. Computed tomography–guided biopsy of thickened omentum revealed poorly differentiated metastatic carcinoma. He died 3 days after admission with a peak white blood cell count of 180,000/μL. Previous reports and pathophysiology of paraneoplastic leukemoid reaction are reviewed. *Department of Internal Medicine, University of Nebraska Medical Center, Omaha †Department of Pathology, Saint Francis Medical Center ‡Internal Medical Associates of Grand Island, Grand Island, NE The authors declare no conflicts of interest. Reprints: Subhankar Chakraborty, MD, PhD, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE- 68198-2055. E-mail: email@example.com. Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.