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Additional Diagnostic Value of Hybrid SPECT-CT Systems Imaging in Patients With Differentiated Thyroid Cancer

Toubert, Marie-Elisabeth MD*; Vija, Lavinia MD*; Vercellino, Laetitia MD*; Banayan, Soraya MD*; Faugeron, Isabelle MD*; Berenger, Nathalie MD*; Meas, Taly MD*; Marzola, Maria Cristina MD; Chondrogiannis, Sotirios MD; Hindié, Elif MD*; Rubello, Domenico MD

American Journal of Clinical Oncology: June 2014 - Volume 37 - Issue 3 - p 305–313
doi: 10.1097/COC.0b013e3182568fdb
Review Articles

Aim: Nuclear medicine has entered a new era of multimodality imaging. Single-photon emission computed tomography/computed tomography (SPECT/CT) hybrid cameras are relatively new diagnostic tools that have been widely adopted and are present in most nuclear medicine units. SPECT/CT instruments allow functional and morphologic images to be acquired as superimposed (fusion images) in a single session.

Methods: The integration of CT enables better characterization of functional abnormalities identified on planar and SPECT scintigraphy by offering structural information. It thus highly improves accuracy compared with conventional scintigraphy.

Results and Conclusions: The combination of functional information and anatomic localization has the potential to influence medical practice with newer imaging algorithms. This review presents the current evidence and potential indications of SPECT/CT imaging in the initial staging, treatment, and follow-up of patients with differentiated thyroid cancer.

*Department of Nuclear Medicine, Saint-Louis Hospital, APHP, Paris 7 University, Paris, France

Department of Nuclear Medicine, Medical Physics, Radiology, Santa Maria della, Misericordia Hospital, Rovigo, Italy

The authors declare no conflicts of interest.

Reprints: Domenico Rubello, MD, Department of Nuclear Medicine, Medical Physics, Radiology, PET/CT Center, Santa Maria della Misericordia Hospital, Via Tre Martiri 140, 45100 Rovigo, Italy. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc