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Comparison of Therapeutic Outcomes Between Surgical Resection Followed By R-CHOP and R-CHOP Alone for Localized Primary Intestinal Diffuse Large B-cell Lymphoma

Lee, Ho Sup MD*; Park, Lee Chun MD*; Lee, Eun Mi MD*; Shin, Seong Hoon MD*; Ye, Byeong Jin MD; Oh, Sung Yong MD; Song, Moo Kon MD§; Lee, Sang Min MD; Lee, Won Sik MD; Kang, Byung Woog MD; Chang, Myung Hee MD#; Cho, Seok-Goo MD, PhD**; Yahng, Seung Ah MD**; Yoon, Sung-Soo MD, PhD††; Kwon, Ji-hyun MD††; Kim, Yang Soo MD, PhD*

American Journal of Clinical Oncology: April 2014 - Volume 37 - Issue 2 - p 182–187
doi: 10.1097/COC.0b013e318271b125
Original Articles: Hematopoietic

Objectives: There is no confirmed treatment strategy for primary intestinal diffuse large B-cell lymphoma (DLBL). In this retrospective study, the purpose is to find an appropriate treatment strategy in patients with primary intestinal DLBL undergoing surgery followed by chemotherapy or chemotherapy alone.

Methods: Seventy-six patients were newly diagnosed with DLBL and received treatment between March 2004 and June 2011. Forty-seven patients were treated with surgical resection followed by rituximab combined with cyclophosphamide, adriamycin, vincristine, and prednisolone (R-CHOP), and 29 patients were treated with R-CHOP chemotherapy alone.

Results: The characteristics of the patients were as follows: the median age was 56.5 years (range, 15 to 85 y) with a female to male ratio of 1.00:1.45. There was no significant difference in patient characteristics between the 2 groups. The estimated 3-year progression-free survival rates (PFS) and overall survival rates (OS) of surgery followed by R-CHOP (surgery/R-CHOP) and R-CHOP alone (R-CHOP) groups were 92.2% and 74.8% (P=0.009) and 94.2% and 80.7% (P=0.049), respectively. In univariate analysis, significant differences were seen in estimated PFS and OS rates when comparing Lugano stages I and II1 with II2 and IIE (P=0.006 and 0.036), low and low-intermediate risk with high-intermediate risk (P=0.004 and 0.000), and surgery/R-CHOP group with R-CHOP group (P=0.009 and 0.049), respectively. In multivariate analysis, there were no independent predictive factors for survival.

Conclusions: Patients treated with surgery followed by R-CHOP seemed to have a higher survival rate than those treated with R-CHOP alone. There were no significant prognostic factors for survival, but there were possible prognostic factors such as Lugano stage, International Prognostic Index risk, and treatment modality for PFS and OS.

Departments of *Internal Medicine

Occupational and Environmental Medicine, Kosin University College of Medicine

Department of Internal Medicine, Dong-A University Hospital

§Department of Internal Medicine, Busan National University Hospital

Department of Internal Medicine, Busan Paik Hospital, Busan

Department of Hematology/Oncology, Kyungpook National University Hospital, Daegu

#Department of Hematology/Oncology, Ilsan Hospital, Goyang-si Gyeonggi-do

**Department of Hematology, Catholic Blood and Marrow Transplantation Center, The Catholic University of Korea, College of Medicine

††Clinical Research Institute, Seoul National University College of Medicine, Seoul, South Korea

The authors declare no conflicts of interest.

Reprints: Yang Soo Kim, MD, PhD, Department of Internal Medicine, Kosin University College of Medicine, 34 Amnam-Dong, Seo-Gu, Busan 602-703, South Korea. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc