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Clinical Cancer Genetics Part 2: Breast

Pollock, Jondavid MD, PhD*; Welsh, James S. MS, MD, FACRO†,‡

American Journal of Clinical Oncology: February 2014 - Volume 37 - Issue 1 - p 86–89
doi: 10.1097/COC.0b013e31823fe657
Review Articles

Since the discovery of proven genetic mutations which predispose people to breast cancer along with the routine availability of genetic testing for such mutations, a number of issues have surfaced regarding potential methods of breast cancer diagnosis, surveillance, treatment, and risk reduction. Many of these issues pertain to the practice of radiation oncology and can affect decisions on management. This article aims to describe some of the more salient features of individuals at high genetic risk for breast developing cancer along with aspects of their tumor biology, clinical natural history, and how the radiation oncologist may address these challenges.

*Department of Radiation Oncology, Schiffler Cancer Center, Wheeling, WV

Departments of Radiology and Neurosurgery, Louisiana State University Health Sciences Center-Shreveport

Department of Radiation Oncology, Willis-Knighton Hospital, Shreveport, LA

The authors declare no conflicts of interest.

Reprints: James S. Welsh, MS, MD, FACRO, Department of Radiology and Neurosurgery, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA 71130. E-mail:

© 2014 by Lippincott Williams & Wilkins, Inc