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Adjuvant Chemoradiotherapy After Curative Resection for Extrahepatic Bile Duct Cancer

A Long-term Single Center Experience

Kim, Kyubo, MD*; Chie, Eui Kyu, MD*; Jang, Jin-Young, MD; Kim, Sun Whe, MD; Han, Sae-Won, MD; Oh, Do-Youn, MD; Im, Seock-Ah, MD; Kim, Tae-You, MD; Bang, Yung-Jue, MD; Ha, Sung W., MD*,§

American Journal of Clinical Oncology: April 2012 - Volume 35 - Issue 2 - p 136–140
doi: 10.1097/COC.0b013e318209aa29
Original Articles: Gastrointestinal
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Objectives To analyze the outcome of adjuvant chemoradiotherapy for patients with extrahepatic bile duct (EHBD) cancer, and to identify the prognostic factors for these patients.

Methods Between January 1995 and December 2002, 86 patients with adenocarcinoma of EHBD underwent curative resection followed by adjuvant chemoradiotherapy. There were 59 male and 27 female patients, and median age was 59 years (range, 34 to 73 y). Postoperative radiotherapy was delivered to tumor bed and regional lymph nodes up to 40 Gy at 2 Gy/fraction with a 2-week planned rest. Intravenous 5-fluorouracil (500 mg/m2/d) was given on day 1 to 3 of each split course. The median follow-up period was 83 months for survivors.

Results Forty-eight patients failed the treatment: locoregional recurrence in 20, distant metastasis in 38, and both locoregional and distant relapses in 10 patients. Five-year locoregional relapse-free survival rate was 70.3%. On multivariate analysis, resection margin status was the only significant prognosticator (P=0.0299). Five-year distant metastasis-free survival rate was 53.6%. Three or more involved lymph nodes had an adverse impact on distant metastasis-free survival (P=0.0334). Five-year overall survival rate was 44.7%, and poorly differentiated tumor was associated with inferior overall survival (P=0.0297).

Conclusions Adjuvant chemoradiotherapy after curative resection can achieve a long-term survival in patients with EHBD cancer. Resection margin status, number of involved lymph nodes, and histologic differentiation are associated with locoregional relapse, distant metastasis, and overall survival, respectively. Distant metastasis was the major pattern of failure, possibly due to the increased locoregional control by use of adjuvant chemoradiotherapy. Intensification of systemic treatment is warranted.

Departments of *Radiation Oncology

Surgery

Internal Medicine, Seoul National University College of Medicine

§Institute of Radiation Medicine, Medical Research Center, Seoul National University

The authors declare no conflicts of interest.

Presented at the 27th Annual Meeting of European Society for Therapeutic Radiology and Oncology, Göteborg, Sweden, September 14 to 18, 2008.

Reprints: Eui Kyu Chie, MD, Department of Radiation Oncology, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul, 110-744 Republic of Korea. e-mail: ekchie93@snu.ac.kr.

© 2012 by Lippincott Williams & Wilkins, Inc