Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Neuroendocrine Tumors of the Gastrointestinal Tract

A Decade of Experience at the Princess Margaret Hospital

Rothenstein, Jeff, MD*; Cleary, Sean P., MD; Pond, Gregory R., MSc; Dale, Darlene, FHA§; Gallinger, Steven, MD; Moore, Malcolm J., MD*; Brierley, James, MBBS; Siu, Lillian L., MD*

American Journal of Clinical Oncology: February 2008 - Volume 31 - Issue 1 - p 64-70
doi: 10.1097/COC.0b013e31807a2f49
Original Article: Gastrointestinal

Objectives: Neuroendocrine tumors (NETs) are uncommon malignancies with variable natural history and often indolent biological behavior. Over the past decade, novel treatment approaches have been developed. The purpose of this study was to review the experience at the Princess Margaret Hospital in treating patients with NET over the past decade.

Methods: The Princess Margaret Hospital Cancer Registry identified 193 patients with NET of the gastrointestinal tract or unknown primary who had their initial visits between 1992 and 2002. A retrospective chart review was performed.

Results: The median follow-up duration was 22.6 months. Demographics of the entire cohort of 193 patients were: male, 53%; mean age, 56 years; age-adjusted Charlson score 0, 71%. Anatomic distribution of the primary location revealed that 35% were from the foregut, 40% from midgut, 11% from hindgut, and 14% from unknown origin. Pathological distribution demonstrated that 72% were NET/carcinoids, 21% were islet cell tumors, and 6% were small cell carcinomas. At presentation, 53% of patients had distant metastases and 46% had loco-regional disease. Curative surgery was performed in 35% of the cohort, whereas radiotherapy and chemotherapy of any intent were delivered to 13% and 34%, respectively. For the entire cohort, 5-year survival was 58% (95% confidence interval, 50%–67%). In multivariate analysis, age, location of primary, and curative intent of surgery were independent predictors of survival. Of patients who underwent curative surgery, 86% were alive at 5 years.

Conclusion: Patients with NET who are offered curative surgery have a good outcome. Distant metastases are commonly found at presentation and portend a worse prognosis. These patients should be evaluated by a multidisciplinary team regarding new approaches to surgery and other therapies.

From the Departments of *Medical Oncology and Hematology, †Hepatobiliary Surgery, ‡Biostatistics, §Cancer Registry, and ∥Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.

Presented in part at the 42nd American Society of Clinical Oncology Annual Meeting in Atlanta, Georgia, June 2–6, 2006.

Reprints: Lillian L. Siu, MD, FRCPC, Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, 610 University Avenue, Suite 5-718, Toronto, Ontario, M5G 2M9, Canada. E-mail:

© 2008 Lippincott Williams & Wilkins, Inc.